Design criteria for a knowledge-based English language system for management : an experimental analysis

Thesis (Ph. D.)--Massachusetts Institute of Technology, Alfred P. Sloan School of Management, 1975."February 1975." Vita.Bibliography: leaves 240-246.by Ashok Malhotra.Ph.D

Making of British India fictions, 1772-1823

This thesis investigates British fictional representations of India in novels, plays and poetry from 1772 to 1823. Rather than simply correlating literary portrayals to shifting colonial context and binary power relationships, the project relates representations to the impact of India on British popular culture, and print capitalism’s role in defining and promulgating national identity and proto-global awareness. The study contends that the internal historical development of the literary modes – the stage play, the novel and verse – as well as consumer expectations, were hugely influential in shaping fictional portrayals of the subcontinent. In addition, it argues that the literary representations of India were contingent upon authors’ gender, class and their lived or lack of lived experience in the subcontinent. The project seeks to use literary texts as case studies to explore the growing commoditisation of culture, the developing literary marketplace and an emerging sense of national identity. The thesis proposes that the aforementioned discourses and anxieties are embodied within the very literary forms of British India narratives. In addition, it seeks to determine shifts in how Britain’s relationship with the subcontinent was imagined and how events in colonial India were perceived by the general public. Furthermore, the project utilises literary texts as sites to explore the discursive and epistemological strategies that Britons engaged in to either justify or confront their country’s role as a colonising nation

Fate of indeterminate microbial keratitis

Background: Previous published literature has shown that there is no significant difference between outcomes of culture positive and culture negative infective keratitis. This study was done to find the outcome in cases of indeterminate keratitis in our institute. Purpose was to highlight the fate of indeterminate microbial keratitis.Methods: Patients presenting to cornea services of ABVIMS and Dr. RML hospital from February 2017 to April 2021 were evaluated for demographic and microbiological assessment, clinical presentation and management.Results: The 188 out of 310 cases were microbiologically positive. No organism could be detected in 122 cases. Clinical prognosis is worse in cases of indeterminate keratitis.Conclusions: Cases with indeterminate microbial keratitis do not show timely and appropriate response which leads to spread of infection resulting in more complications and less CDVA

Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics

A large number of polyphenolic and heterocyclic compounds, i.e. 4-methylcoumarins, 4-methylthionocoumarins, xanthones, pyrazoles, pyrazolylacrylonitriles, flavones and isoflavones have been tested for their antioxidant activity towards NADPH-catalysed liver-microsomal lipid peroxidation with a view to establish their structure-activity relationship. Inhibition of microsomal lipid peroxidation by 7,8-dihydroxy-4-methylcoumarin (DHMC, 2) and 7,8-diacetoxy-4-methylcoumarin (DAMC, 3) was intriguing. We also found that dihydroxy and diacetoxy derivatives of 4-methylthionocoumarin were more potent in comparison to the corresponding coumarin derivatives in inhibiting TNF-α induced expression of ICAM-1. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of ICAM-1 in human endothelial cells. 1,4-Dihydroxyxanthone (10) showed enhanced antioxidant activity as well as the inhibition of the expression of cell adhesion molecules, such as ICAM-1, VCAM-1 and E-selectin on endothelial cells in a concentration and time dependent manner. Antioxidant activity of different pyrazoles and pyrazolylacrylonitriles and antiinvasive activity of flavones and isoflavones against solid tumors have also been studied

Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives

Enzymes, being remarkable catalysts, are capable of accepting a wide range of complex molecules as substrates and catalyze a variety of reactions with a high degree of chemo-, stereo- and regioselectivity in most of the reactions. Biocatalysis can be used in both simple and complex chemical transformations without the need for tedious protection and deprotection chemistry that is very common in traditional organic synthesis. This current review highlights the applicability of one class of biocatalysts viz. ‘‘lipases’’ in synthetic transformations, the resolution of pharmaceutically important small molecules including polyphenols, amides, nucleosides and their precursors, the development of macromolecular systems (and their applications as drug/gene carriers), flame retardants, polymeric antioxidants and nanocrystalline solar cells, etc